5_MeO_DMT

5 Meo Dmt india is a research chemical psychedelic of the tryptamine class, four to six times more powerful than its better-known cousin, DMT (N,N-dimethyltryptamine). It can be found in a wide variety of trees and shrubs, often alongside DMT and bufotenine (5-HO-DMT), as well as one species of toad. 5-MeO-DMT can also be synthetically produced.

In Central and South America, 5-MeO-DMT is most often sourced from Anadenanthera peregrina (yopo or cohoba) and Virola theiodora—both of which are traditionally harvested to make psychoactive snuff.

It’s also found in the milky white venom of the Sonoran Desert Toad (Bufo alvarius/Incilius alvarius; aka the Colorado River Toad ), which is native to the southwestern United States and northwestern Mexico. Venom harvesting has put pressure on the population of this ecologically sensitive species. It’s currently listed as imperiled or locally instinct in several states in the US. Seeking out alternatives sources of 5-MeO DMT, such as synthetic or plant-derived versions, is strongly recommended.

About 5-MeO-DMT

In keeping with its ceremonial use among indigenous Amazonians, 5-MeO-DMT shows great promise in the treatment of certain medical conditions. In fact, a single inhalation of the substance has been shown to greatly improve general well-being and mindfulness as well as reduce the symptoms of psychological disorders.

While research into 5-MeO is limited, a few studies have supported the anecdotal evidence. In a recent preliminary study, 42 participants who took 5-MeO reported high levels of life satisfaction and mindfulness as well as lower levels of depression and anxiety. The effects persisted for four weeks, when a follow-up assessment was completed.

These results support the findings of a survey of 362 people who had taken 5-MeO. After using the psychedelic, 80% of respondents reported improvements in anxiety and depression.

5-MeO has seen a meteoric rise in popularity over the past few years as anecdotal reports of its potential as a healing agent have come to light. This has incentivized some bad practices among guides and other practictioners, including everything from overharvesting and the ecological strain on Sonoran Desert toad mentioned above, as well as sexual abuse and even unintended deaths in several documented cases.

What to Expect

Vaporizing or smoking 5-MeO powder is the most common route of administration. The effects are usually felt within the first 30 seconds after consumption, peaking from 1-15 minutes and lasting for up to half an hour. In taking synthetic 5-MeO, a threshold dose is around 1-2 mcg, while a moderate-to-strong dose is 5-10 mcg. If naturally derived, the threshold dose is 5-10 mcg and a moderate-to-strong dose is 20-40 mcg.

When swallowed, doses are generally higher, but also show generally unreliable results. Other less common routes of administration include sublingual (under the tongue) and injection.

The effects of 5-MeO come on strong, often with a loss of physical coordination and control. Users experience bright colors, moving environments, or recursive patterns, and perhaps even “environmental orbism” at higher doses. However, visual effects are limited. Unlike DMT, 5-MeO isn’t known for its visionary properties. The experience is more often described as a “perspective shift” characterized by physical, emotional, and conceptual effects.

Dosing

5-MeO-DMT doses are different depending on whether the substance is synthetic and naturally derived.

Synthetic

Small: 3-6 mcg
Medium: 6-10 mcg
Large: 11-15+ mcg

Toad

Small: 10-20 mcg
Medium: 20-40 mcg
Large: 40-60+ mcg

Potential Benefits

5-MeO has been used as a healing agent by South American shamans for thousands of years, partially due to its ability to occasion mystical-type experiences. While research into the drug is still limited, recent studies are backing up these ancient claims.

In a survey of 362 adults, 80% of respondents reported improvements in anxiety and depression after using 5-MeO, as well as an increase in well-being and life satisfaction. More than that, improvements were directly related to the intensity of the mystical effects felt during the experience. Respondents that had intense mystical experiences also reported higher rates of the experience’s personal meaning and spiritual significance. 5 meo dmt India

Risks 5-MeO-DMT

A recent study from The Journal of Psychopharmacology found that 5-MeO is safe to use and has a low risk of health consequences.

However, there are some things to be aware of before diving into an experience. 5-MeO should not be taken with MAOIs, including some antidepressants. Combining them may cause severe hypertensive symptoms (elevated blood pressure, heart rate, and temperature), seizures, long-term kidney damage, serotonin syndrome, and even death.

In the past few years, however, interest in 5-MeO-DMT has grown, along with research. In one study, researchers gave 5-MeO to mice and found a major down regulation in mGluR5, a receptor involved in the reward mechanism of drug abuse.